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Maternal, Paternal Alcohol Use Affects Success of Assisted Reproduction
NEW YORK (Reuters Health) Feb 21 - Alcohol consumption by both men and women affects pregnancy outcome in couples undergoing in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT), according to results of a study published in the February issue of Fertility and Sterility.
In a multicenter prospective study, Dr. Hillary Klonoff-Cohen and colleagues from the University of California, San Diego, examined the effect of male and female alcohol consumption during IVF and GIFT on reproductive endpoints in 221 couples with female infertility. Main outcome measures included egg retrieval, transfer, fertilization, pregnancy, miscarriage, live birth, and multiple gestations.
For every additional drink per day, women had a 13% decrease in the number of eggs aspirated (p = 0.02). The risk of not achieving pregnancy was increased 2.86 times with alcohol consumption in the month before the IVF or GIFT attempt (p = 0.05). Alcohol use 1 week before the attempt was associated with an odds ratio for miscarriage of 2.21 (p = 0.03).
Paternal alcohol consumption 1 month and 1 week before IVF or GIFT increased the risk of not achieving a live birth by 2.28 and 2.43 times, respectively (p = 0.04). The risk was increased by 3.14 (p = 0.02) and 8.32 times (p = 0.006) for those who drank one additional drink per day during the first visit and for the week prior to sperm collection.
If these findings are confirmed, "clinicians should recommend that couples abstain from alcohol consumption at least 1 month before the attempt to maximize the effectiveness and success of the IVF and GIFT procedure," Dr. Klonoff-Cohen and colleagues advise.
Fertil Steril 2003;79:330-339.
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